Journal of Medicinal and Pharmaceutical Chemistry Research

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Estimation of insulin resistance and creatine kinase among Iraqi patients with type 2 diabetes mellitus

Maysoon Khalid Hussein; Perry Habib Saifalla

Volume 4, Issue 12 , December 2022, , Pages 1193-1200

Abstract

Type 2 diabetes mellitus (T2DM) is a disorder in which the body’s ability to control and profit glucose as fuel is impaired. Too much sugar flows into the circulation due to this ... Read More Type 2 diabetes mellitus (T2DM) is a disorder in which the body’s ability to control and profit glucose as fuel is impaired. Too much sugar flows into the circulation due to this chronic disease. Therefore, it can be defined as a group of metabolic disorders which can be characterized by different factors such as insulin resistance and followed by different complications. It has an influence on a variety of physiological bodily organs, making them less effective, including skeletal muscles. The aim of this study is to determine the activity of serum creatine kinase (CK) in Iraqi patients with T2DM. A total of 93 participants (68 T2DM divided into three groups: group I (19) patients with diabetic duration (˂5 years), group II (19) patients with diabetic duration (≥5 to <10 years), and group III (30) patients with diabetic duration (≥10 years), as well as 25 healthy people as a control group gave their consent and participated in the study. All samples were collected from patients attending at Mustansiriya University, from National Diabetes Centre for Treatment and Research who were selected by the supervising specialist to be free of diabetic complications. Fasting serum glucose(FSG) was measured by the glucose oxidase method for patients and control group Insulin was measured using ELISA kits. Also, Homeostatic model assessment of insulin resistance HOMA-IR (IR), Homeostatic model assessment of β (HOMA-β), and The activity of total CK were determined for the patient and control groups. In the present study, FSG, insulin, IR and HOMA-β were a significant increase (P≥0.0001) in T2DM patient group when compared with control group. During examination, the T2DM group II and III showed a significant increase in creatine kinase activity as compared with the control group, with p-values of (0.048, and 0.013) respectively. In T2DM patients, there was a positive correlation between CK activity and duration. In this study, There was also association between hyperglycemia and total CK activity.