Document Type : Original Research Article

Authors

• Nadia Betti ¹
• Jaafa S. Shia ²
• Abdul Amir H. Kadhum ³
• Ahmed A. Al-Amiery ^{4, 5}

¹ Materials Engineering Department, University of Technology-Iraq, Baghdad 10001, Iraq

² Department of Pharmacy, Al-Farabi University College, Baghdad 10001, Iraq

³ University of Al-Ameed, Karbala, 56001, Iraq

⁴ Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia

⁵ Energy and Renewable Energies Technology Centre, University of Technology, Baghdad 10001, Iraq

Abstract

The rational design of 4-hydroxycoumarin derivatives is crucial due to their therapeutic significance and structural versatility. This study focused on synthesizing and characterizing various coumarin derivatives using spectroscopic techniques such as Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR), and elemental analysis CHN. The antibacterial and antifungal activities of these derivatives were assessed against specific bacterial and fungal strains, respectively. The results revealed strong microbiological activity with, inhibition zones ranging from 6 to 27 mm against bacteria and inhibition percentages ranging from 6% to 26% against fungi. Furthermoe, the compounds exhibited significant antioxidant properties with scavenging percentages ranging from 27% to 91% as determined by the DPPH radical scavenging assay. These findings underscore the potential of coumarin derivatives as versatile therapeutic agents with promising applications.

Graphical Abstract

Keywords

• Coumarin derivatives
• antibacterial activity
• antifungal activity
• antioxidant activity
• green chemistry

Main Subjects

• Antimicrobial agents