Document Type : Original Research Article


1 Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

2 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, 1665659911, ACECR, Tehran, Iran

3 Department of Physical Therapy, Children’s Hospital Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran


In the present study , a novel method for the production of silk nano fibers are presented . In this way , a mechanical and easy technique is used instead of toxic and costly chemical methods . Also , the separation of silk nano fibers from the cocoon was carried out by mechanical homogenizer and probe ultrasonic homogenizer . After the preparation of silk nanofibers , the product was characterized by Fourier transform infrared spectroscopy (FT - IR) and scanning electron microscope (SEM) . The results were compared with previous techniques and the advantages of the new method were investigated.

Graphical Abstract

A novel inexpensive method for preparation of silk nanofibers from cocoons


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