Document Type : Original Research Article


1 Department of Human Health, Institute of Fundamental Medicine and Biology, Kazan Federal University, Russia

2 Department of Microbiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Russia


As a result of a study of patients with abscesses and phlegmon of the submandibular triangle, 39 patients aged 20 to 30 years received treatment with an immunomodulator. Before and after treatment of wounds, the immune status was assessed: local immunity of the oral cavity (SIgA), indicators of cellular immunity (blast transformation reaction with phytohemagglutinin - PHA LTT (phytohemagglutinin lymphoblast transformation test)), indicators of humoral immunity (IgA, IgG, IgE). The results obtained proved the clinical efficacy of the immunomodulatory drug, which accelerated the healing period of abscesses and phlegmon of the submandibular triangle in this group of patients.

Graphical Abstract

Efficiency of healing of wounds of abscesses and phlegmons of the submandillar triangle


Main Subjects

[1] T.G. Robustova, E.A. Bazikyan, A.I. Ushakov, A.V. Dayan, N.S. Serova, A.A. Ushakov, Rossijskaja Stomatologija, 20081, 61-68.
[2] A.W. Evans, Br. Dent. J., 2001190, 343-346.
[3] D.J. Coluzzi, Dent. Clin. N. Am., 2004, 48, 751-70.
[4] B.K. Normurodov, J.A. Djuraev, A.Z. Shaumarov, J.M. Akhmedov, Cent. Asian J. Med. Sci., 2020, 2020, 116-130.
[5] J.G. Powers, C. Higham, K. Broussard, T.J. Phillips, JAAD, 2016, 74, 607-625.
[6] T.S. Gupta, J. Stuart, AJGP2020, 49, 544-549.
[7] D.M. Altmann, Immunology2018, 155, 283-284.
[8] S. Von Gunten, B.S. Bochner, Ann. N. Y. Acad. Sci.2008, 1143, 61-69.
[9] J.F. Miller, M. Sadelain, Cancer cell2015, 27, 439-449.
[10] T.A. Ahmed, B.M. Aljaeid, Drug Des. Devel. Ther., 2016, 10, 483-490.
[11] I.Y. Kim, S.J. Seo, H.S. Moon, M.K. Yoo, I.Y. Park, B.C. Kim, C.S. Cho, Biotechnol. Adv.2008, 26, 1-21.
[12] N.R. Ling, E. Spicer, K. James, N. Williamson, Brit. J. Haemat., 1965, 11, 421-431.

[13] G. Mancini, A.O. Carbonara, J.F. Heremans, Immunochemistry, 1965, 2, 235-254.