Document Type : Short Communication


Department of Pediatrics, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia


Multiple pituitary hormone deficiency (MPHD) is a disorder that can cause short stature and delayed puberty due to the deficiency of several pituitary hormones. This case report aimed to deliver a rare case of multiple pituitary hormone deficiencies, focusing on the diagnosis approach and therapy. A thirteen-years-old boy came with a main complaint of short stature with a height of only 101 cm. The growth chart showed that the patient was below the third percentile. The Tanner stage was prepubertal. There was no history of short stature, delayed puberty, and hormonal disorders in his family. Hormonal tests showed deficiencies of GH, FT4, FSH, LH, and testosterone, and normal serum levels of TSH. Those were indicating growth hormone deficiency, central hypothyroidism, and hypogonadotropic hypogonadism. Patients received levothyroxine and recombinant human growth hormone as hormone replacement therapy based on the etiology. The evaluation of therapy is carried out every 3-6 months. MPHD may be idiopathic or caused by hereditary disorders. The underlying cause of MPHD remains unknown. Further screening and diagnosis are required to evaluate risk factors and the best future therapy.

Graphical Abstract

A boy with short stature, be aware of multiple pituitary hormone deficiency


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