Rahadian Zainul; Arif Nur Muhammad Ansori; Ahmad Affan Ali Murtadlo; Teguh Hari Sucipto; Viol Dhea Kharisma; Muhammad Hermawan Widyananda; Bayyinatul Muchtaromah; Amaq Fadholly; Muhammad Khaliim Jati Kusala; Vikash Jakhmola; Maksim Rebezov; Sukma Sahadewa; Putu Angga Wiradana
Abstract
Dengue fever, caused by the dengue virus, is a significant global health concern, with millions of cases reported annually. The absence of specific antiviral treatments or effective ...
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Dengue fever, caused by the dengue virus, is a significant global health concern, with millions of cases reported annually. The absence of specific antiviral treatments or effective preventive measures has fuelled the urgent need for a dengue vaccine. This provides a comprehensive review of the development of a dengue vaccine, summarizing the major milestones, challenges encountered, and recent advancements in this field. This study explores various vaccine strategies employed, including live attenuated vaccines, inactivated vaccines, recombinant subunit vaccines, and viral vector-based vaccines. In addition, the manuscript discusses the clinical trials conducted to evaluate the safety and efficacy of these vaccine candidates.
