Journal of Medicinal and Pharmaceutical Chemistry Research

Demographic trends in COVID-19 prevalence at a primary hospital of Mashhad: a screening study

Shadi Saghafi Khadem; Zohre Arzaghi; Behrang Rezvani Kakhki; Maryam Ziyaei; Fatemeh Maleki; Ehsan Bolvardi; Mahdi Foroughian

Volume 6, Issue 7 , July 2024, , Pages 842-854

https://doi.org/10.48309/jmpcr.2024.436430.1095

Abstract

This study intricately explores the demographic dynamics influence on infection rates, disease severity, and mortality attributed to the virus. Through a meticulous examination of these ... Read More

Serum troponin level relationship with prognosis of nontraumatic cerebral hemorrhage

Yeganeh Youzbashizadeh; Morteza Saeedi; Zahra Abbasi Shayeh; Ehsan Bolvardi; Maryam Sobhani; Mahdi Foroughian; Maryam Ziyaei; Fatemeh Maleki; Amir Masoud Hashemian

Volume 6, Issue 4 , April 2024, , Pages 447-455

https://doi.org/10.48309/jmpcr.2024.430139.1057

Abstract

Background and aim: Assessment of the prognosis of the intracranial hemorrhage (ICH) is important in case of patients’ follow up and management. It is reported that there might ... Read More Background and aim: Assessment of the prognosis of the intracranial hemorrhage (ICH) is important in case of patients’ follow up and management. It is reported that there might be some links between serum troponin levels (TPI) and ICH. However, there is a gap of knowledge in case of nontraumatic cases. The aim of this study was to investigate the relationship between TPI and prognosis of patients with non-traumatic cerebral hemorrhage.Method: This retrospective cohort study was conducted on all non-traumatic stroke patients referred to the emergency room of Ghaem Hospital (AJ) on patients with confirmed ICH in CT scan. Patients were included in the study after obtaining consent from them or their legal guardians. Brain CT scan was used to determine the location and volume of bleeding, midline changes, and presence of intraventricular hemorrhage (IVH). The bleeding volume was estimated using the formula (ABC)/2. The primary troponin (cTnT) test was performed within 12 hours of the onset of symptoms for each patient. A serum cTnT value ≥0.01 ng/ml was set as the cut-off value, and then the patients were divided into two groups: normal troponin and increased troponin level, and also their prognosis was determined based on the ICH Score and Predicting Mortality after Acute ICH table. Next, after 3 days, all patients in both groups were contacted and their disease status was determined based on the Modified Ranking Scale. The collected data were subjected to statistical analysis by SPSS.Results: A total of 387 patients were included in our study, including 214 men (55.3%) and 173 (44.7%) women. The average age of the patients was 66.16 years and ranged from 19 to 95 years. 81 patients (20.9%) had increased troponin based on the determined level. In addition, 174 patients (45.0%) died during hospitalization. The mean of ICH Score was 2.37 ± 0.99 and the mean of Modified Ranking Scale was 3.24 ± 2.49. There was no significant difference in terms of troponin level (p=0.250) and gender (p=0.508) between those who died and those who were discharged with partial recovery.Conclusion: There was no significant relationship between troponin and the outcome of non-traumatic brain hemorrhage patients, but after adjustments, the troponin levels were increased. However, it seems that the level of 0.01 ng investigated in our study is not suitable, and it is possible that other levels will provide better results.

Evaluation of predictors of mortality in patients with COVID-19: a systematic review and meta-analysis

Amirhossein Darvishzadeh; Hadi Hasani; Reyhaneh Behrouzinezhad; Alireza Bahmani; Marzieh Delavar

Volume 4, Issue 5 , May 2022, , Pages 392-401

Abstract

Evaluation of predictors of mortality in patients with COVID-19. In the present study, articles published from January 2019 to December 1, 2021, were reviewed in PubMed, Scopus, Web ... Read More

Evaluating the association between blood pressure and mortality in Covid-19 Pneumonia: A systematic review and meta-analysis

Marzieh Delavar; Zeinab Kuchaki; Reyhaneh Behrouzinezhad; Mahdieh Khodabandeh; Amirhossein Darvishzadeh

Volume 4, Issue 4 , April 2022, , Pages 279-28

Abstract

This research sudy evaluates the association between blood pressure and mortality during the Covid-19 epidemic. A software program was employed to manage electronic titles. The 95% ... Read More

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Keywords = mortality

Demographic trends in COVID-19 prevalence at a primary hospital of Mashhad: a screening study

Abstract

Serum troponin level relationship with prognosis of nontraumatic cerebral hemorrhage

Abstract

Evaluation of predictors of mortality in patients with COVID-19: a systematic review and meta-analysis

Abstract

Evaluating the association between blood pressure and mortality in Covid-19 Pneumonia: A systematic review and meta-analysis

Abstract